All Ren´Py games crash instantly.

[Kidjumbo]

So ive recently got myself a brand new Desktop PC instead of my old Laptop.
The Latop used to run everything just fine, but my Desktop can run any games that use Ren´Py and some other engines wont launch either.
What do i do?

 

[Nightcrawler]

Try compatibility mode also check your av, Have had to white list several renpy games on bit defender as it kept quarantining the exe