I tried that but still didn`t work, BTW great game, one of the last games I play after all others use generic artwork.
That's odd. Okay, the only other thing I can suggest is this:I have the same issue. I tried deleting the persistent file, but it still does the same. I can't run the game, and yes I played it before.
Make a backup of your save folder somewhere outside your %appdata%
Then delete the save folder inside your %appdata% and try launching the game.
If it works, then try putting back your save files one by one and see which one is causing the game to not boot up anymore.
Let me know if this worked. It's an issue I've been having with my Renpy games for years and noone has been able to give me a good solution for it yet.