I played a lot of games and the one with the most choices that matter by far is
College Daze. Most scenes are written differently depending on your previous choices and of course many scenes are available or not depending on your choices.
You can replay the game many times and find many new scenes (unless you make the same choices of course). Whenever I replay the game, I ask myself "What am I going to do this time ?"
There is no grind at all. There is a simple energy and stats management system. There are cheats included that will allow you to play without the energy limitation and just manage your stats (this is how I like to play) or cheat completely with max stats/energy.
And there is a lot of content !