Difficult to say.
Did you really install RenPy into
E:\SOFTWARES\Real\RealUpgrade\htm\drivers\DRIVERS\html box\renpy\renpy-7.4.7-sdk\
?
Because my first thought is that something in a path called
\RealUpgrade\
sounds more like malware than something deliberately installed.
drivers
makes me think some sort of crap software that says it's "a systerm tuneup" type package.
My first port of call would be to run some anti-malware programs. It's been a while since I actively went searching for malware, but you might want to try any or all of these:
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Not sure they are all currently relevant, but it's a starting point.
I'm not saying it
IS malware. But a quick google search seems to say it might be. But that's the problem with google... if I expect that to be the answer... then that's the answer I find.
I suppose the easier question is "did you deliberately install something called "RealUpgrade"?" Because if the answer is no, then you probably needs to do a full malware AND anti-virus scan too.
Edit: The other reason my mind went to malware was that some malware works by hooking into a registry entry for file associations. Though the fact you only see it when launching RenPy projects might mean "simple fuckup" rather than actual malware.