It's definitely the type of game that makes a lot more sense on a 2nd playthrough (especially since i skipped a LOT of lines the 1st time around), you catch a lot of foreshadowing of future events or interesting reactions from characters to certain lines that you can deduce meaning from given future revelations. That's why I'm extra careful about catching stuff that I don't know anything about, but might be a foreshadowing of a future reveal in my 2nd playthrough.I remember that when I first started playing I got the impression that something had recently happened that completely broke and shattered Sensei which is what caused him to jump at the very beginning. I kept thinking that the whole world was either his brain trying to fix himself as he was in a comatose state in a hospital or that somehow Maya had created the world to heal him but had since been punished for trying to do so(This was mostly because of how cryptic maya was and all the knowledge she seemed to have but refused to provide). I think the latter theory doesn't really work anymore too well anymore due to all the supernatural stuff unless the theory about Maya being some sort of fallen angel turns out to be correct.
To be fair, I think I also took the first happy event a little too literally so I thought that maybe Maya was actually just a husk filled with always hungry spiders which explained how she never liked letting people see her eat but also that she just devoured everything in an instant. That happy event also let me think that she was being punished off-camera which is what we were seeing and then further compounded how she feels and reacts to Sensei.
I feel like I need to replay it now that I understand a lot more about the lore and the world to see how my impressions have changed or to see anything else I might have missed or not understood at the time.