As my super duper knowledge of all that stuff. YEP (none). I just tried it to test

And haven't had other complains that it didn't work.
C:\Users\
%USERPROFILE% \AppData\Roaming\TalesOfAndrogyny --> Doesnt work.
C:\Users\
%USERPROFILE%\AppData\Roaming\TalesOfAndrogyny --> Works.
C:\Users\
%USERPROFILE% \AppData\Roaming\TalesOfAndrogyny --> Doesnt work.
%USERPROFILE% \AppData\Roaming\TalesOfAndrogyny --> Works
%USERPROFILE%\AppData\Roaming\TalesOfAndrogyny --> Works
Without the spaces it would work most of the time.