Alright, finally got to this... Have only done one playthrough so I can't comment on any differences depending on skill routes. Also haven't read everyone's views of the game because I wanted to go in as unspoiled as I can be at my advanced age.
I feel like this is going to suffer from one of the number one issues I had with LoF (Leap of Faith) and that's simply too many potential love interests (especially generic white chicks). Other than that there are some bugs with the interface or lack of clarity about what order to do things in, not too surprising when I am playing a beta. In the club scene in particular I clicked on Teagan before I'd clicked on anyone else and the game wouldn't advance after that.
Overall, this was really strong for a first release which is to be expected when it is coming from an established developer such as Driftygames. I like how there are numerous questions we want/need answered but I am worried that it could be overly ambitious. The hints of a possible Manchurian Candidate or The Prisoner type of game are intriguing and lead to a belief that the beginning scene with Ana is after many training montages in the future. However, we will have to wait and see if that is true.
Personally, was hoping for a simple tale of a boy meets Teagan and lives happily ever after making cute redheaded babies with her... or just practicing a lot.