I like the topic! Let's see...
1) Always look for an incest patch if necessary. If there is one but it's out of date for the current version of the game, I generally wait to play the game until the incest patch is updated. If there's no incest patch but I can change the relationship of characters, I always make it the most natural-seeming incestuous relationship.
2) If a game uses Honey Select or the first words somebody would use to describe it are "good story" or "futa," I don't play that game.
Note: good story is great, but it shouldn't be the most important part of a porn game. The closest equivalent is 'hot' or 'sexy' story, in terms of descriptions that are good to have for a porn game. Futa is a dealbreaker, though.
3) If there's a choice of gender, I always pick 'male' for the main character. If there's an option to turn the main character into a female character, I always pick 'No' or 'Fuck no' or 'Eww, definitely not.'
4) When there's a choice of ladies to romance, I always pick the best combination of the following to seduce first, in order: most closely blood related to the main character, most reluctant to have sex with the main character (seduction, btw. Like, I have to bring her more flowers and do more stuff for her to get to bang her. Not the other kind of reluctant), biggest tits. For example, in Summertime Saga (with the patch applied), Jenny and Debbie are pretty much equally related to the main character and have roughly equally large jugs, but Debbie is comparatively easy to bang and Jenny takes more work, so I prefer to seduce her first. Similarly, Ava is harder to bang in The Company than Dakota, so I put more of my efforts into seducing Ava first. Also, dem taits.
5) If I expect to get bored of a game before finishing it, I tend to skip the scrawny flat-chested virgin girls rather than the busty interesting girls.
6) If stats or money matter to gating content in the story, I try to solve those problems as soon as feasible. Especially if things are timed, this is generally a priority even over banging my favorite ladies early.
7) Re-evaluate the whole game after every major patch. Ever since the incest debacle a few years ago, I find myself asking whenever a game makes a major change: do I still like this game, do I still give a shit if it exists? This has helped me decrease my habit of watching (and complaining about!) projects from people like Fenoxo, Akabur, and MrDots. It also helped me pick up projects like SuperPowered, Summertime Saga, and Man of the House again after they got some issues that had cropped up in their games sorted out.