For me it would be modern day classical Europe, stuff like Lucca where there's streets that have been there hundreds of years, but also a club that just opened a year prior, it has a castle but also a busline. So basically a historical setting but not taking place in the past. Or Carcassonne, it has wide 6 lane roads, but also a city wall that's hundreds of years old and you can imagine knights patrolling the grounds and the walls, but it also has very modern underground parking garages. I think it could be a fun setting to be in a place where it's easy to think back to the past of the place, rather than actually being back in the past when all of it was new.
If I try to pick something from your poll, I would say family villa on the coast/on an island. Large pretty rooms, a sea breeze through open doors and a few steps from white sands with a few more steps into the sea/ocean. None of these settings truly bother me and I could probably enjoy a game set in any, but depending on the setting it may need to work harder to convince me.
And I remember what the girls were like at my college, and it was quite immature, to the point it felt like we were all just adult kids. So college girls do little for me generally. Now if it was about trying to fuck all the soccer moms in the PTA as the gym teacher, and you don't deal with any students during the game, or they are just there as a way to get to the mother/aunt/guardian/moms/social worker? Sure. Any setting can work, and nothing will work for everyone. But true originality can't be found in anything so broad as the setting, so you'd have to set it apart with mechanics, graphics or story, or a mix of the three.
What if there's a psychotic bitch that you want to hate fuck, and her love language is dead pidgeons? I imagine it wouldn't make for a great character, but it would be memorable at least, regardless if she's in college, a villa or on an island.