I believe that you can achieve a greater range of emotions and detail this way.
On this, in particular, I disagree, but only because I've been forcing my artist to reach a much greater range of emotions than is average using Daz. The real problem here is that many daz devs have made their games using the straight out of the box poses and expressions, not bothering to play at all with the sliders and mechanisms available to adjust those very over the top expressions to fit the scene. You can even combine sliders if you know what you're doing, or manually adjust them yourself.
As to what I prefer, well, I have to say that most 2d games don't appeal to me, but that's not because I don't like 2D art. It's because 2D art requires the use of Sprites as a shortcut. I prefer things to be in scene. characters sitting around a table, talking, laughing, crying, etc as necessary. Not, character sitting around a table, and then a sprite comes up to show them laughing or crying or talking or whatever. This goes for 3D as well. I don't play games with sprites unless they offer me something to make up for it.
Coceter Chronicles, Offcuts, and I think that might be it, are the only games I can think of that I'd recommend that use sprites, and both have an amazingly well written game supporting them. In the case of Coceter, it also gets a little leeway on being an RPGM game. As to Offcuts, I just loved the characters and the characterization so much that I couldn't not allow it. Offcuts is 3D but the characters are as expressive as any manga.
The other thing I take issue with on 2D is the number of them that use 1 shot for 10 lines of dialogue in a sex scene or something along those lines. Seriously, change things up, give me multiple poses and appropriate focus to facial expressions and the like as things occur. Manga can do it, there's no reason a game can't.
So, in the end, I vote for 3D, not because I don't like 2D art, but because I don't like 2D game design.