Pretty good writing, the art is pretty beautiful, and the background is awe-inspiring. The interaction between characters feel genuine and interesting. Unfortunately, there is not much content here, nor adult content. There is thus not much of a reward for becoming more feminine or masculine. The protagonist, for example, tells us that his transitioning negatively affects him and his family, but this has not been indicated in his daily interactions with them.
This has resulted in the story feeling forced, flat and unfulfilling.
The characterizations for other characters that are not Vincent and Samantha need work. The idea that the main character, Ethan, never needs to go outside his comfort zone and interact with the characters like Jordan is artificial. Not to mention these characters don't really add much to the plot and can be ignored entirely in regard to the main character.
One can also even go as far as to say that Vincent and Samantha aren't very good examples of high-quality characterization in themselves. They rarely delve deeply into their interests and there are no behavioral ticks that they have that separates them from each other or the other surrounding characters. This leaves them to be two bland love interests that can be exchanged for each other and the Player unable to tell the difference. This is not something one should have in any romance story.
The madame, who brings a magical method in order to transition in the first place, is an example of terrible writing. Her olden way of speaking, though creating an atmosphere of mystery, actually grates irritatingly upon the modern-day setting making her a, perhaps, intentional eye sore in a story that otherwise flowed nicely. I would suggest you drop her entirely.
Keep trying though! The best writing is a balance! This is definitely one of the better well written stories I have read on here.