This is the downside to 3D models (and the anime art style), they're overused and everyone has seen them. I haven't really become bored of them yet though and the anime art style in games have been around since forever. Plus, at least with DAZ, the morphing options, when used, can create completely unique characters.
I've never been impressed with HS or KK models but DAZ models are only getting better and better to me. There are tons of character options and they can be morphed and combined into something completely different. It's also pretty easy to do so I'm not sure why other developers don't do it more (other than laziness of course). As an example from my game, one of my characters has been morphed into a model that is completely different from what I used as the base.
Here is the character from my game:
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Here is the model used as a base:
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Completely different. Though this included some texturing work as well as morphs. Not saying the model in my game is necessarily better than the base model, I simply wanted to show what was possible.
As mentioned, DAZ is getting better and better, the jump from V4 to Genesis 7 was absolutely massive and then to Genesis 8. Now we're at Genesis 8.1 and is by far the most sophisticated 3D character base that is commercially available and easily used. You CAN create very good looking models and scenes with little to no uncanny valley feeling with enough practice, but some people are more sensitive to the uncanny valley effect than others.
As for genitals, you can produce a decent variety of these too, but might require extra textures and morphs. Dicktator v3 (and onwards) is probably the most customizable penis asset with tons of morphs and texturing options. For vaginas there are two commonly used options, NGV8 and Golden Palace. Both are fine, though I prefer NGV8 for variety in morphing options.
All in all, even though anime art has been around forever, I'm still not bored of it and DAZ is just getting better. What I'd like to see more of though is a more stylized set of DAZ models in addition to the current focus realism. There are some options that exist for this, but they're rather few.