Well.
Lighting is a big topic.
How to light a character in a scene depends on many factors. what is the best result is subjective.
There is no one solution that fits everything.
But always ask yourself, Where is the light coming from in the scene?
Usually there are some rules you can follow.
Use Three-Point Lighting. (Key Light, Fill Light, Back Light)
Consider the Style / Atmosphere / Mood of the scene.
For emotional scenes, shift the color to a more tempered one etc.
Add Eye lights/glare, small highlights in the eyes can bring the character more to life.
Etc.
Use additional visible light sources like lamps.
And|Or add a softbox to have more diffused shadows.
Avoid front-facing light, it flattens the face, have a slight angle.
Avoid symmetry, asymmetrical lighting looks more dynamic.
For Animation/Cinematic scenes use Blocking techniques with lighting.
You have to play around and experiment to see what you like best for your scene.
you can also try out different 
	
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But you also have to consider for realistic renders.
Just adding in good lighting may not be enough.
You also need to have materials on the characters that can interact with the light.
Example, usage of subsurface scattering etc.