So does siding with the humans when they raid the village lock you out of anything? The walkthrough doesn't really mention anything.
That really depends on what you did beforehand:
No matter what, you get a quest on the Beast route to turn the Orchard into basically your own future harem, which doesn't amount to anything much yet.
If you killed Kaali, Mountana is a pain in the ass, though it's kind of broken regardless.
If you spared Kaali, the Beast route opens up a lot more and you get to hang out in Mountana. Of course that means you get to keep banging Kaali, but you also get access to a literal fat pig (if that's your thing), get info on the Witch for your "origins" quest, and in the future it looks like you'll be able to seduce the Beast King's Secretary (though let's be honest, there are still characters with "gift/flirt/clothes" menu options that have been sidelined since 0.2X).
I don't think the Human Route has any characters locked behind it yet? It looks like the Queen and Ophelia will be, but they appear to be further from implementation than other characters (PURE SPECULATION ALERT). Honestly if they become available that would make running a second save for the Human Route worth while.