Dana & Andrea from "Dreaming of Dana"
Dana is intelligent, beautiful, funny, kind and confident, all in the proper dosage. She isn't shy showing off her body early on, but that doesn't mean she is going to let you do just anything to her. The way to Dana's heart feels genuine and not rushed. It is clear that she has feelings for you, but it is up to you to bring them out in the open.
Andrea is just a sweetheart. At first glance she just seems to simply be a dumb slut, who willingly whores herself out for money, but there is so much more depth to her. Her past experiences with her family and lack of guidance in her life, has left her fragile and desperate for someone to watch over her and protect her. Andrea is the first female I felt like protecting, rather than fucking, although the sex is a nice bonus.
Megan & Melissa from "Acting lessons"
Megan is cute and gorgeous. She is trying her best to find her own place in life and has slipped so many times that is starting to lose faith in herself. It is genuinely satisfying to see her confidence builing up again, all while opening up to you more and more.
Melissa. What can I say, other than that I would love to pound her step-father into the ground, for daring to ruin such a lovely girl and make her retreat so far into herself that she is scared to show her true self to anyone. I want to see her happy, more than anything else in this game. I would put myself into celibacy for the entire game, if it was the means to make her happy.
Jessika from "Redemption for Jessika"
This is probably my favourite girl of the list. This girl is just the perfect mix of just about anything you could want. She is kind - yet stern, confident - yet insecure, happy - yet sad. She is also beautiful and funny. All of this makes her a really interesting character and someone I would love to be with in the real world.
There are many other from different games, but these are the ones I remember most clearly as of today.