since no one has commented yet, I'll give my unnecessary 2 cents
As you probably already know, the format can depend 1 on limitations and 2 on what you want to prioritize.
computers tend to be the most flexible, especially if the content comes from a game where you can run custom code. If this was for mobile, you have to deal with a vertical screen limitation, and maybe design the comic for infinite scrolling like with webtoon comics. Computers with a horizontal screen is one such limitation, where a page orientation may not be best.
you say it comes down to dev preference, but I disagree. not just because its an escape goat excuse, but if it is down to preference, then preference can be arbitrary, and arbitrary design is shit! If you want to find a good or best comic layout or plan of action, you don't think in 'preferences' you think in terms of 'priorities.'
A good example is the layout of comic pages. if made by a professional, everything is placed with purpose, by knowing how the viewers eyes will subconsciously move across the page. Even art centuries ago did this, where invisible lines would guide the views focus to the key subject of a painting, even if the subject wasn't in the center of the painting.
I bring this up because to figure out what to prioritize, I think the 12 principle of animations are a good default to start with before doing anything more complex. the main one that is most applicable is #4 staging, the most complex rule, or in video/photography you would considered this 'composition'. Simply put, you figure out your priorities based on controlling what the viewers experience, much like rhetorical theory.
you can control what the viewer is noticing by keeping in mind that the viewer can only focus on 1 thing at a time. what is great about comics is that you can communicate a lot of things at once, unlike the slow pacing of a VN. The issue is to control the flow of information and not overload the viewer, especially if you focus on VN like experience and then switch to comic experience.
you need to prioritize what kind of information should and should be given all at once. for example I would avoid comic layouts since I like to give more of a TV show like experience when there is something to focus on, ie two characters talking to each other. But if there is a lot going on, or I want to say a lot is going on without going into too much detail (ie a quick fight or sex scene), I can use a comic as a snap shot reel.
But other than that, the other main use I have for comic layouts is for simply giving context, lots of insignificant panels with a main center panel. think of comics strips, where they have set up panels, and a final punchline panel. You want the punchline panel to have kick to it, you don't want the viewers to get caught up focusing on the set up contextual panels too much, but you also don't want the viewers to skip right to the punchline without reading the set up first. for this reason I often like having the set up be the biggest and near the top right (following normal wester reading order left to right, top to bottom), the punchline panel near the bottom right, second biggest, and any contextual panels (even if it's just a small side joke of a character sneezing because their name was called) tend to be on the opposite diagonal (top right, bottom left), and I only allow small contextual comics in the dead center when I want to indicate a break between the smooth read between the set up and punchline panels, ie a pause it time as a character hesitates, a flashback or jump to another location and back, anything that makes the viewer pause for a bit rather than just smoothly reading through left to right top to bottom...
but I don't have any good examples of this practice I can share yet. so maybe I just sound like I'm rambling! but other than over thinking, I just like to add text balloons with throw away sound effect or dialog to indicate the world is alive, such as character trying to talk when in the middle of a crowd... or just sex sounds
Edit: the other example I can think of where I want to use comics is sort of hinted at when I mentioned fight scenes, but for sex. I'll use a comic like format if a character is experiencing complex emotional experiences (ie various facial expressions) in a short amount of time. This is because I sees some amazing animations out there, but because of being 3D and fast, its hard to catch all the little nuances, so in art form I think having a comic works best because you can fake a short time duration by using a comic format so that viewers aren't spending too much time on each image (thus less tedious of an experience than say something like a line by line story in a VN).