What mods do i need to turn on or off to get the gam working?
For me it worked with all mods, except the redundant ones of course.
Meaning you only use one skin for each building (tavern, sanitarium, blacksmith, etc.), one loading screen pack, one inventory expansion pack (the bigger one of course).
For class mods, just pick the ones you like, or turn them all on at once and ignore the ones you don't like.
For other mods, you can use them if you want, I'll just list the ones I disabled and why:
Full roster start - Just didn't like it, stumbling upon new classes and heroes is part of the early game
Video Hentai All Open - For progression sake kinda feels nice to have something to work towards.
Bosses Only Endless Quest - Self-explanatory, I just didn't feel like I wanted the boss gauntlet instead of the regular Farmstead
Kindest Dungeon - Doesn't really work properly, so I just disabled it
Warmth Meter - Didn't like the changes, the original torchlight is more exploitable
Faster Combat & Faster Darkest Dungeon - Didn't really need to speed things up
Also, one of the mods will give enemies and bosses random buffs. If you feel like that makes the game too hard or annoying, I've listed how to remove them without disabling the mod in the thread above.
If you can't get the game working at all, some of the more taxing mods supposedly are the all skin set, and sexy fallen heroes. Try disabling those if your PC can't handle everything at once.