For me, I fall into the Depth of Field bracket for most scenarios, especially character interactions.
The main reason for this, I feel it me with a deeper sense of immersion. However, it's not the be all and end all.
When creating scenes, I also feel it's a tool I can use to focus the players attention.
As I'm in the process of creating a few render, I decided to see how they looked with and without the depth of field.
For the first scene:
For this, I still prefer the DoF personally (even if the background is a bit over blurred and the TV light is way too big). This is mainly because I'm keeping the focus between the interaction between the two characters and not on other things (like the guys dirty fingernails and exactly what the envelope says).
For the second, it's probably a bit more obvious where the players focus will be however:
Here again, I feel I prefer the DoF one, mainly, because this time it's from the perspective of the guy and hopefully, it's telling the player where he's focused on and not just the player.
So for me, I'm definitely in the DoF camp (of course, there's always exceptions), but as mentioned earlier, do what you like as that's what you will know best.