Honestly, considering how little it takes for some people here to go after a dev like crazy, only stopping once the dev either gives in to their demands or either goes incommunicado or abandons their game in general, I would say that a radical shift in topic will probably either anger your supporters or be of absolutely no interest to them.
And people who support you or like your work, like it for the content, probably at least as much as for the quality, so a massive change in topics or kinks won't go down well with most of them.
I consider myself quite open and not everything has to be curtailed to my specific tastes, but if a game goes completely against my interests, why would I like that?
If any of my favourite devs suddenly started a new game which was NTR-centric, with lots of femdom and maybe even stuff like guro or scat, which I really can't deal with at all, I think I would probably stop supporting and let them know that this drastic shift in tone was not to my liking. Probably not exactly that neutral and polite.
Not like harassing or attacking them, I'd say my piece and leave for greener pastures.
Other changes like going from story-centric to porn centric, from serious to ridiculous, that I can go with. Of course, it still depends on the quality, but I can go for a game that's merely about porn, if it doesn't take itself too seriously and vice versa, if the story-centric game is well written and the story is interesting.