The advantage of the female MC is the sexual disconnect. If the protagonists is male, most players, myself included, will want them to do the fucking. With a female MC you can have others fuck as well and most players don't mind, basically female MC's are best for a free for all fuckfest.
A typical female game is corrupting the lead, which we won't have here, and the appeal of corrupting males is trickier because most players go in with the mindset of "I'd fuck her" but it can work, corrupting a priest, a married man, but because its a man, you have to put more effort into selling the idea that they don't want to fuck her, at least initially, she can't show her tits and then they're doing it. Then of course you can have her corrupt other women, a teacher gives up his soul if you can get one of his students into his bed.