I took a quick look. Feel like you completely removed volume node, I guess for rendering time purpose (I assume you render with Cycles). Not sure if you let any SSS at all or went fully without it (seems like it).
The Denoiser is really kicking you in the nuts, it is really mandatory?
Have you considered Eevee instead, for such speed rendering?
Vic8.1(eevee->), it's far from perfect but can hold some neat details with micro tiles while still being quasi-instant.
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