This game:
https://f95zone.to/threads/pale-pure-v0-8b-aretired.1418/
by aRetired uses a similar style.
I think it worked in the context. The problem with that game graphics (as far as I remember) were the backgrounds and the strange / unnatural lighting.
Still I did like his games.
On the other hand, if you are capable of making good Daz renders, then I don't really see the point. If your renders are sub-par for some reason (e.g. lack of good graphics cars and/or skills) then this might be a good way out.
Maybe you can also play around with giving Honey Select renders this treatment and see how that works out. Honey Select is a lot easier and faster to work with than Daz, in my opinion.