I assume live2d with unity is the way to go?
Ren'py also have support for live2D.
But anyone who decide to use live2D should first take the time to read everything regarding the subscription. Their
You must be registered to see the links
say that, "Upon purchase of a subscription plan by the Customer, Live2D grants the Customer the right to use PRO version of the Software and accompanying services during Subscription Term (as hereinafter defined) in accordance with this Agreement and the terms listed on the Webpage".
I don't know live2D and therefore can not be affirmative on the subject, but it looks like the day you stop paying the subscription, you've to also remove all your games from the market. By itself it's not a problem, the yearly fee starting at US$ 129.55/year, what isn't this much. Yet, it's more than what (more or less) half of the authors on Patreon earn yearly.