I can't tell for sure, but i think there's nothing that stops you unless you are using some version for steam (saving your data in the cloud that is limited), the only thing that stops you is just the amount of common events, items, variables etc, (for example, the limit for the number of max items in the game is 999 in rpg maker VX Ace) but if you manage to avoid flooding your game with those things you should be fine since there are no restrictions for space in general to my knowledge. Somebody corrects me if i'm wrong.