I've been playing a game recently called "
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" on DLSite, though I've seen many translations of the title and am not sure any of them are correct. It's pretty much the ideal game in this genre, focused totally around building up negative status effects and making battles harder. You initially play a super powerful magical girl heroine but can quickly end up lactating, addicting to lesbian advances, and all kinds of other things if you're not careful. As the heroine gets hornier, she also puts less effort into battles so she'll do less damage, miss more often, and get hit more easily by the enemies' erotic advances (they only use ero attacks). Unfortunately there's no translation, and being able to read the text is fairly important to understand a lot of the game's systems and how to win the levels without brute-forcing everything the hard way. Still, it's so good that I'd recommend looking into it if you're a fan of those kinds of games, just be aware, it's exclusively focused around tentacles and lesbians, and even then the tentacles never penetrate. It's mostly about teasing the heroine into submission.
If you're looking for something you can just play right now easily with a proper decent translation, definitely try
Marle - The Labyrinth of the Black Sea. You play as a powerful archmage who's already had a great dragonslaying adventure before the game, and is basically taking some personal time to search for a mystic artifact. Her powers are soon suppressed by a lust aura when she gets there and she has to delve deeper to unearth the secrets of whatever's going on. The game has a lot of tentacle content, I'd say 33-50%, but there's also human men, orcs who will place lust symbols, and other creatures. The game can actually start to feel very hard to complete if you build up too many negative statuses, which is exactly the kind of thing I like and it sounds like you do too.
By the same group, there's
Risa and the Succubus Grimoire. Unfortunately, it's only machine-translatedMake sure to pick up a patch
here to avoid some crashes related to machine translation. The poor quality translation is honestly a real shame mostly because Marle's story and setting were quite good, and it's hard to enjoy the writers' work in this state. Anyways, this game features
exclusively sex between the heroine (and occasionally a priestess friend) and one or more human men, which has its own fun flair. She's constantly surrounded by large groups of men, so it feels like it makes sense to give in. You're not nearly as strong as Marle, more of a run-of-the-mill thief/rogue who often must resort to consumable healing items, bombs, and other such things to get by (think Edge from FFIV, if you've played that). The game also features some great post-loss scenes where you get a chance to fight back at first from a disadvantaged position (like being tied up but eventually breaking free after the enemies get a few free turns), but as the MC gets lewder then she stops fighting back and the scenes change.