She's immune to status effects, so you really have to brute force her. Her only weakness is seduction but even that deals pitiful damage. I've finally beaten her with regular penetration, ignoring her weakness and that barely worked. She healed too fast otherwise. She later appears even stronger. There are also more human enemies like her. I found Haruka. Also futa. SHe also seems to return stronger at different location after beating her (She was easier. Strengh focused and without gimmicks).Never heard of her, but would recommend trying poison and sleep status effects, poison can stack up to deal massive damage, and sleep might stop her from healing herself. Plus of course scan her to make sure that you're using the right attacks.
They seem to specifically come with Miniaturization mod as side bosses so you won't find them in normal game, but not even mod wiki mentions them.