Yes, but the success or failure of a game will depend on several factors, not only if the theme is popular: story, art (3D, 2D), program in which this fact (renpy, unity, rpgm, etc), fetishes, writing the story, are only some, (in my opinion the most important), that you must take into account.
I know, that only asks if someone is interested in playing it, but if you ask maybe it's for something ... equally lucky, the theme would promise to harem.