With the last update lot of code was overhauled by the Dev's, so theres quite a few new bugs that need to be addressed. A few are game breaking, but a couple can be worked around.
In v0.5, the more drink you consume it seems to keep stacking a debuff where you need to go to the bathroom more frequently, and this bug keeps stacking, so you might have to pee every 5-4-3-2 minutes, all the way down to 10-15-30 second intervals.
Also, I would only recommend playing this version of the game with the cheat menu enabled. I'd freeze time to avoid the bathroom bug altogether, or at the least be able to reset your bathroom need manually when it depletes.
Unfortunately, the cheat menu now breaks and becomes completely unavailable after 'some' play time or some other bug? Pressing the key to bring up the cheat menu stops functioning, and even rebinding the key does not bring it up.
There is a fix to get the cheat menu back by starting New Game. This new game will automatically go to slot 2, so your save file 1 will be safe. After starting the new game, skip the tutorial. You can rush and go to the bed to save, but the cheat menu will be working right after you start this new game. Quit and go to your original save and your cheat menu should be working for a while again. Rinse and repeat the steps if you lose the cheat menu again.