Hmm, there's a
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regarding this issue on Virtual box forum. I have just took a quick look at it, but apparently disabling the 3D acceleration solve the problem ; but obviously slow down the display.
This being said, there's others result and all seem to point on the direction regarding the culprit: A badly/wrongly tweaked OpenGL library.
Therefore another solution, but that you'll have to apply game by game, is to press
shift
+
g
then select as "renderer" something else than automatic choice and OpenGL. But then you'll have to restart Ren'py, what mean that it's not a really suitable solution, unless disabling the 3D acceleration really impact the speed of the games.