I think that'd make you an exception -- because what you're talking about, having Holly sleep with some random guy(s) behind her boyfriend's back is pretty much definition of NTR. It's like saying "swimming in a pool has nothing do to with being submerged in water, it's just wearing a bikini". Which, you have to admit, is a pretty absurd stance.
I can like women in bikinis without liking seeing women swimming.
I'm just talking about the descent of the character from pure to corrupted. Can cheating facilitate that? Of course, but my point was that enjoyment doesn't come from the cheating itself, but from the overall descent, and this can be done in ways that don't necessarily include cheating. Like Ivy and Lena encouraging Holly to be more body conscious, and encouraging her to take up modelling while being dismissive of her own personal interests (that's more of an Ivy one, but honestly slut Lena should have more options to do that too.)
But it is mostly a matter of perspective. I don't consider it ntr because I'm not sitting here salivating over Ian getting cucked out of his perfect relationship. I'm just interested in Holly being encouraged to cheat as a vehicle to further her own personal fall in the same way that ORS does for Lena, or GGGB did for Ashley and Eva.
Now that I think about it, GGGB also had examples of characters going from corrupted to being redeemed, such as Jack and Jessica, but ORS doesn't really have characters like that, although I guess there's potential with some of them.
The suggestions given to Holly by Ivy and Lena are all about getting her comfortable with having sex, something she's had little experience with. So when she's in relationship in which she is having sex and is comfortable with it, it's perfectly reasonable she doesn't need to heed advice which amounts to making her do the same thing she already is doing. It's not unrealistic she'd behave differently in two pretty much opposite situations. ("i haven't been laid in years" vs "i'm getting laid regularly and enjoying it, thankyouverymuch")
Realistically, Holly can be in a relationship, having sex and still be concerned that she's not enough for Ian, given that he's suggested to be more experienced than her, and depending on the player choices, literally hanging out with 3-4 models weekly. I personally just find it a bit of a stretch that she supposedly comfortable in that situation, and I think her dialogue as well reflects a continued doubt of her self-worth that Ivy and Slut Lena could prey upon. As one optional path for her character. I like to play the pure route too.
I guess we'll just have to agree to disagree then. To me, this idea in the way you present it is out of character not just for Holly, but also Lena and Ivy, given how they've acted in the game so far.
C'est la vie