Minerva will break the relationship if Ian is dating Holly, so you would need to avoid that. Minerva is married, but she also starts taking care of herself in the earnest if she has affair with Ian, so who knows.Question is: can you form a lasting relationship with Minerva or Emma?
Emma is completely laid back about relationships, but iirc she isn't against it per se, just didn't find anyone who'd make her consider it. So, again, who knows.