Here´s the thing for me. I am a person who "hates" that everything must be interconected in a story. To give an example, remember GOT? When a lot of people created theories about the Night King being a Targaryen, a Stark and those things? I hated that. Why must it be something we know or we can relate to something known? It´s more beautiful when something big is made by a literal no one.
Back to the thing after this unnecesary thought, I wouldn´t like Wade+Emma, first because they don´t fit, and why a person which is clearly going through a depression state would try to bang Emma while having a gf. That´s why I also don´t like the theories about Gillian or Cherry being involved with Axel or Mike. But afterall this is just my opinion. I trust a lot about what Eva has in mind cause I think she´s giving incredibly great personality stances for the characters. And I also love reading the theories and posibilities you bring here.