Well as someone else said hes regenerated himself from a single cell, you could see Wolverine also could regenerate himself from a single drop of blood in the comic CommanderShepard posted earlier. And in the Deadpool 2 movie he said tried to kill himself almost every way possible... I am sure he destroyed his head multiple times too. And I pretty Wolverine tried to do same. Also considering the fact that depending on which Marvel Universe you're in, they use to drop off Wolverine into the middle of Nazi / Hydra installations where I pretty sure hes been blown up and shot to smithereens a bunch of times... So I pretty sure the whole keep your head or spine intact thing is just BS they made up to make it seem like you can kill Deadpool, Wolverine, X-23, etc... but in reality you just can't.I thought as long as his head is mostly intact, his body will slowly regenerate from his head.
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