Wow, that is a lot of hate for Goblin Teeth. I'm curious as to why. It's stat inefficient with only two stat points, but they're both valuable stats. Correct me if I'm wrong but ATK/MATK give +4 damage whereas DEF/MDEF only give -2 damage, right? And especially on hard mode where it's more difficult to keep sufficient DEF/MDEF to only take 1 damage per hit, it seems preferable to upgrade ATK/MATK and AGI in the early game. Really, rather than seeing Goblin Teeth as a terrible ingredient, I see it as an early game ingredient. Thoughts?
I would say you are kinda Right. But Goblin teeth is a good candidate for the worst item still.
In hard mode at least, it is kinda hard to have sufficiently MATK to do more than a negligible amount of dmg with spells against the demons and bosses that truly matter. So the +1 MATK is useless early game. After the early game you have access to much better items than goblin teeth for MATK and in general. Also it does not allow to «specialize » aura or your slime. And I am almost sure you cannot use it for alchemy or platings.
Other worst item candidates would be:
ogre bone, the agi loss hurts a lot but in some niche builds this item makes sense.
avian feather, this is a strictly worse slimy fluid (which is also kinda abundant) as LUCK is clearly trash. This is one of the last ones I use for my slime and never for aura. At least, it is useful for a quest and even 2 agi item is « ok »
The other items either allow you to make platings or alchemy or have strong stats, so they are fine.