As long as you save where the game asks you to save, you won't miss anything that's significant. In those cases the routes have branches which are exclusive (like Helen or Mia and Mrs. Johnson or June or a threesome) and you'll have to reload your save to chose the other option.
Next to that there are some minor things which you may miss, if you play the game the wrong way, like Yumi giving Harold a blowjob in the park instead of eating donuts, if you've finished Mia's story and chose Helen before that point of Eve's story and there are of course some small story connections, like Roxxy/Jenny reacting differently depending on their progress.
But those things won't really matter in the big picture. As said, as long as you save when the game tells you to save, you'll be fine.
Edit: @
burneric:
The game has a pretty cheerful, light mood, and while there may be some minor instances of betraying trust, it's certainly nothing that would make players who like those things happy. I'm fairly certain that it's going to stay that way and that there won't be too much drama. After all, Rump has got his thotbot by now.