So apparently it is impossible to beat Grimm with the toxin debuff on unless RNGesus lets you, but you literally cannot progress without beating him. I haven't seen design this annoying since vanilla Fallout 4's storyline...
edit: And of course, the moment I complain about it, RNGesus decides to stop screwing me over. Thanks murphy. >_>
edit 2: Okay, who the hells thought it was a good idea to lock the STORY PROGRESSION just because you missed ONE CHOICE?
Now I have to replay the chapter because I made ONE wrong dialogue-choice? This is like some EA Shit.
"Yes, you can totally play our game. Just do it twice to pass through this ONE scene, or you are completely soft-locked from progressing!"
Edit 3: Okay I was frustrated as hells, starting to calm down, sorry if bits of this post feel bitchy.
Lots of potential in this game, but some of these features are so badly thought-out it seems like something someone'd use on steam to force you to play past the 2-hour refund limit, just so they can make more cash.
Don't get me wrong, the replay feature is nice and all, but locking actual story-progression behind it just feels...wrong.