Are you planning on doing translation for games or do you want a program to hook into a game translate on the fly?
Hook programs
TA - TranslationAggregator
TAHelper
VNR - Visual Novel Reader
Atlas - Trial no longer available and not free (You can find cracks for it but becareful)
Mecab - Dictionary
edict - Dictionary file
Manual
Translator++
TA
TAHelper
Atlas
Mecab w/ jParser
edict - Dictionary file
I can't help you setup or use any of these but there are plenty of guides out there.