I think it would be nice if there were a toggle at startup to turn off skill decay. After seeing some scenes 100 times, they just aren't that interesting any more (like the gym scene, like the bar/club scenes, etc).
I also wish there were a way to make the New U machine work even if you are already female (perhaps even transitioning you back to a different male character, or with a huge fee attached), but I can see how that might be a bit more complicated to balance.
Finally, IDK if there's any good way to put this into the pill sales routine, but when I'm working for several days in a row I find it difficult to remember which of the three "probed interest" choices happened most recently, especially when I'm trying to go fast. I think it would be nice if there were a reminder there somewhere, since a salesman would probably write something on a post-it note as a reminder to suggest on what they should focus during the call.