I'm looking into this right now, you're absolutely right that there's nothing that should justify that kind of performance hit. Any chance you could DM me a save of your problematic game so I could take a look? Debugging is always easier with a test case.
Unfortunately, it is stating 'None' and this does not fix the bug.
Hmm, I'll have to take a closer look to figure out what's gone wrong. Would you be able to DM me the saved game that's giving you issues? You should be able to find them in
C:/Users/YOURNAME/AppData/Roaming/Renpy/AVeryFullHouse.
Now that the game has a good amount of m/f content in it they're a very good candidate for my focus in the next update cycle or two. I'll be putting it to my patrons with a poll in the next couple of days, and the choice is probably going to boil down to some version of "focus on MCILF + girls", "focus on boys + girls", or "focus on new outfits for the girls".
I really want to do a super cut-down version that's just the skull and some g-string ties (or just a skull pasty? so many options!). We'll get there eventually!
I actually like them the way they are, they're already pretty tiny, too small and they risk ceasing to be skull panties altogether, though I can also see the appeal of even tinier, and a skull pasty. Ultimately I just want to see Nerd jerking off with them (potentially in them, hell maybe even while she's wearing them).