In order for that to potentially happen there have to be interactions between the characters. Blocking such interactions based on a throwaway remark would be counterproductive.
• EP.8
Tommy "It's not like you will see them after you ditch them."
MC "No? What if you want to stay friends?"
Elena "Do you think that's a good idea, given that you dated her?"
• EP.9
MC "She's sort of my ex-girlfriend."
John Boy "Yeah? You still stay in touch with your exes, huh?"
MC "Well, she's it."
John Boy "I never did that. I usually cut all ties and move on."
MC "You could end up as friends after."
John Boy "I suppose. But what happens after that?"
John Boy "Are you gonna keep your ex around your next girlfriend?"
The existence of these dialogues makes me believe that there is an option to block Zoey completely from the MC's life. As I said, Zoey herself recognizes this in Ep.10.
All main girls save from maybe 1-2 potentially chosen can have shaky relationship with MC who has dumped their collective asses in Episode 8. And yet MC continues to see them after what's effectively a break-up. Singling out Zoey and basing this on something as flimsy as "Derek is better friend" would be really far-fetched.
She may continue to appear in the plot, but if the MC moves on, their relationship won't be much different from Sage and Chad who meet every day, but are just complete strangers to each other.