Again, it's hard to talk about canonical J/M, because DPC has given us many opportunities to avoid this route. My stance on all immersive/RPG games where there is a lot of variation in the development of events is this: only the backstory is canonical.
For example, if we take the Witcher trilogy, then the book source is canon - everything that happens in games is not canon and depends only on our choices. Books says that Yennefer is canon, but I would say "Fuck her" and go with a redhead

So I would say that: MC backstory with Zoey is canon, but how you will decide her route it's all on the player. Even Interlude is not canonical on 100%, because we able to change Zoey personality in DIK/Chick.