So if I may add my 2 cents to our collective advice for the (lucky?) rookie, here goes:
1-Brienne and Atugi are best girls personality wise & best team mechanics wise, can't go wrong with them.
2-Helping Arona is only good for unloking the big tittied orc girls in her war camp (they are better than Arona IMO) and also getting Tui some cool berserker subclass after she talks to Arona once that quest is over (don't worry she won't cuck you, Tui is a good girl) which makes her a really good attacker if you're playing a healer to keep the Tui/Brienne team combo as solid as possible.
3-If you wanna be the most OP shit ever despite Savin's hardest attempts of "No PoWeR fAnTaSy" then go Charmer, Teasing does mass damage like nobody's busyness and the few things immune to it can be EASILY taken care of by either using Summons or Acid Flask (a power you can steal after you're done with the first half of the game)
4-If you into impregnation then Kiyoko content is good and personality-wise she is good too, Kinu is also adorable until you let them out of the amulet (then she becomes TOBS spite project) so my advice would be interact with them if you're into impregnation, enjoy the astral plane fox wife and (if you choose to) after you free them SKIP any conversation with Kinu and focus on the fox-wise, Kiyoko is still gratefull and loyal to you for pulling her ass out of existential crisis.
5-Clementine is among the best NPCs in this game, I've yet to hear anyone complaining about her or Vari for that matter so have fun!