TiTS tf's: give you unique perks and mechanics that make you FEEL DIFFERENT from other tf's, some NPCs REACT to your race and scenes change more than just different ADJECTIVES, have UNIQUE EXCLUSIVE SCENES, and in general YOU FEEL LIKE YOU HAVE PLAYER AGENCY
CoC2 tf's: you can use alchemy to not have to reload a save over and over
close call between the two systems i think.
but in all seriousness, TiTS has weak tf's but also has good ones, being a centaur/naga might lock you from half of the game for just a handful of scenes... but at least you can BE A NAGA OR CENTAUR