Every time I see such reckless attempts, I feel sorry for people wasting time, money and talent.
Sprite Game is not made this way.
If a Sprite game is made in this way, the capacity of the game will exceed 50 giga by the time the game takes the form.
I don't know how many computers have the memory to withstand that huge capacity.
Realtime compress supports only Block Compress.
In order to use Block Compress you must use only the Power of Two resolution and force dithered.
That's why it's not easy to make a high-resolution sprite game.