Combat in this game is pretty easy to win,just who are you fighting against btw?(there are some fights that are scripted loss eg-Bailey with 2 thugs).Use pepper spray as much as you want,you can pretty reliably dodge the police in this game.
Main combat stats are physique and willpower(to resist pain),improving Science(pain reduction) and English(specifically 'Demand' and 'Apologize' speech options) grades also helps. Some transformation will further increase power of certain attacks for eg-Wolf(for increased bite power) and Demon(for increased headbutt damage). Bite deals pretty substantial damage so try setting that up by targeting Breasts or Pussy with mouth,just don't try it with Penises as that will count as Rape and will result in Control loss. Using 'Apologize' Speech option will reduce pain inflicted upon PC(effectiveness depends on English grades) . For late game,focus on getting 'Sadism' and 'Masochist' traits.