if you are on a Seidr run you should be able to summon a pup wolf that helps for the fight (instead of Manning -the guy giving firearms), and if you are on a Seidr run you should also work more with serums because that branch increases their power soon (in other words, prepare Valhalla serum, Asbru invocation and Potent huldra essence for that fight).Any hints?
Note also that the big wolf has a powerful attack every other round, so time the Defend power accordingly (you won't be able to block all of them but you should aim at blocking the maximum possible amount). Also remember that Tag Team and Regroup increase the base damage so try to use them early in the cycle (Regroup especially). And if you have the pup I believe it lacerates (slowly bleeds the enemy) so it should always go first in a cycle.