I always prefer stories that are interesting. It has to use the fetishes in interesting ways. I don't get turned off on how it makes me feel. Is it vanilla or extreme is not an important consideration for me. The things that I nope out of are the tags - gore, extreme violence (of the sexual kind). So as long as the creator is honest with the tags, I'm fine and will try out anything that has the tags I like. That said if You decide midway during development to introduce tagged content that I don't like, even that is fine. You should not be beholden to your audience. You don't owe us anything (and considering we are playing for free, you don't owe us (at least) a full game). We are only here to experience your vision. And that's what makes this worth it.
Once I get in and the tags match my preferences, the presentation has to hook me in one way or the other. Whatever you implement - sissy, dom, transformation, ntr, vanilla, etc - it should be something that you like. If you seek to please whatever audience you collect here, it would be a recipe for burnout and disaster. In short, create experiences that you would enjoy and fap to. Everyone else be damned. Best of luck.