Run it through the Ren'py SDK. If you download the sdk and put the folder in sdk folder, either the mac or pc files, and play the game through the sdk application, you don't have to deal with permissions every time you download a new ren'py game. You also don't have to worry about which version you download or dealing with winebottler. It's also a convenient way to organize games. Every mac user should download the Ren'py SDK, it makes everything way easier and more convenient.The game won't open on MAC version, (OS is 10.13.1) and yes, I allowed the application to run through security.