Personally, I wonder if Mass Effect might be a good place to set a game. Think about it; the Collectors waste you like normal, and when Lazarus brings you back, Commander Shepard has perhaps suffered a *tiny* bit of brain damage, and is now on a quest to fuck the Normandy. Make sure Kaiden died on Virmire, and you can have all the women you'd want, and a good reason in-universe to be able to get away with the shit you typically pull in trainer games (being the only hope the galaxy has to save themselves from the Reapers, and potentially a SPECTRE to boot, gives you a lot of leeway, I imagine.)