I'm so tired of the argument about tags like ntr. I too hate it with all my heart, and I would never play a game that can't make me skip it. With that being said, the argument will never end because the people arguing are never truly responding so it just a repetition over and over again. Those against it are annoyed that a game with an interesting story/universe has ntr in it, often very unclear if it's optional, not optional, voluntary or rape. The ones liking ntr respond with saying that they should just not play it and leave instead of complaining. These arguments will never cancel each other and will only continue.
To answer the question:
Ntr, scat/water play(including whatever other gross tags exists.), female protagonist, female domination, furry, gay, trans.
Special mention to the type of game where the protagonist is some sort of hero destined to save everyone or something, gathering a party/following of girls to aid him (and have sex with) only to end up the least notable and special out of all of them. I can't stand that type of game, the dev has a really cool concept, but the mc is either just so far under his party when it comes to anything, or just not notable, having crude weapons when the people around him have mind blowing powers that he can never hope to match, yet even though the mc is that unnoteworthy he is still the ''leader'' and everyone wants to sleep with him. This type of game is usually built and advertised like a power fantasy, yet you are nothing compared to everyone else, but you still manage to win somehow. Usually there is some sort of training/build up to reach your true strength, but that is more often than not inadequate to make you better/cooler than your followers/enemies. I find it incredibly irritating to start a game claiming that you will be this great hero when you really are neither great nor a hero. It's possible to make amazing side characters, but if you don't have or know anything special that actually makes you someone worth following it will gets irritating quite fast.